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Exploring Drug Bioaccumulation and Stabilization with Respect to Endolysosomal Ion Homeostasis Using a Systems-Based Mathematical Modeling Approach
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Exploring Drug Bioaccumulation and Stabilization with Respect to Endolysosomal Ion Homeostasis Using a Systems-Based Mathematical Modeling Approach. |
| 개인저자 | Woldemichael, Tehetina B. |
| 단체저자명 | University of Michigan. Biophysics. |
| 발행사항 | [S.l.]: University of Michigan., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 216 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438125643 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Gustavo Rosania |
| 요약 | Even though most of the FDA approved drugs currently out in the market and in the process of development are weakly basic drugs, the bioaccumulation and stabilization of these drugs are not well understood. For this purpose, we use a model drug, |
| 요약 | To test our hypothesis, we adapt a systems-based mathematical lysosomal ion regulation model, which consists of lysosomal membrane proteins, such as the proton-pump known as Vacuolar ATPase (V-ATPase), Cl-/H + antiporter known as CLC7, and membr |
| 요약 | Collectively, our computational results as well as the CFZ-H+ Cl- physicochemical properties in relation to the ion contents and pH of the microenvironment suggest that the physiological and preferential phase-transition-dependent accumulation a |
| 일반주제명 | Biophysics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
