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Cardiomyocyte Cell Cycle Revealed by FUCCI
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Cardiomyocyte Cell Cycle Revealed by FUCCI. |
| 개인저자 | Alvarez, Roberto, Jr. |
| 단체저자명 | University of California, San Diego. Biology. |
| 발행사항 | [S.l.]: University of California, San Diego., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 120 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438110045 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, San Diego, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Mark A. Sussman. |
| 요약 | Rationale: Pre-existing cardiomyocytes and resident cardiac stem cells are limited in their capacity for substantial regeneration in postnatal endogenous mammalian myocardial repair. Evidence for adult cardiomyocyte proliferation remains inconcl |
| 요약 | Objective: Authenticate fidelity of proliferative markers as indicators of de novo cardiomyogenesis and subsequently delineate the post-mitotic status of postnatal cardiomyocytes. |
| 요약 | Methods and Results: Cardiomyocyte specific FUCCI expression driven by the alpha-myosin heavy chain (alphaMHC) promoter was utilized in conjunction with traditional proliferation markers to identify cell cycle status of postnatal murine cardiomy |
| 요약 | Conclusions: Proliferation markers used to identify de novo cardiomyogenesis failed to distinguish cycling cardiomyocytes after injury. Adult cardiomyocytes upregulated cell cycle activity in response to sham injury but failed to complete regene |
| 일반주제명 | Biology. Cellular biology. Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
