상세정보
Export to Refworks부가기능
The Role of Host-associated Factors on Metazoan Microbiome Assembly
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Role of Host-associated Factors on Metazoan Microbiome Assembly. |
| 개인저자 | Brooks, Andrew W. |
| 단체저자명 | Vanderbilt University. Human Genetics. |
| 발행사항 | [S.l.]: Vanderbilt University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 279 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088302736 |
| 학위논문주기 | Thesis (Ph.D.)--Vanderbilt University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Bordenstein, Seth R. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Gut microbiomes, the genetic repertoire for millions to trillions of microbes residing throughout each metazoan's digestive tract, are shaped by their host and environment. Composed of up to 500 times the genetic diversity of the human genome and distributed across more than 1,000 microbial species, microbiomes result from ecological assembly of microbial communities known as microbiota. The advent of high throughput genetic sequencing hastened the characterization of microbiota and microbiomes, revealing an under-appreciated diversity of microbial taxa, ecological compositions, and functional capabilities. It is within these gastrointestinal communities that this body of work aims to assess variation associating intrinsically with host physiology, genetics, metabolism, immunity, and evolutionary relatedness, as well as extrinsically with lifestyle, diet, environment, and sociality. Research presented here addresses a diverse set of hypotheses about how animal and human hosts shape their associated microbiomes. This breadth of topics reflects the newly appreciated importance of host-associated microbiomes, and exemplifies the many important questions that still need to be addressed in such a fledgling field. While disparate questions were addressed in each project, the results presented here reveal novel insights about how animals and humans shape their complex communities of associated microorganisms. |
| 일반주제명 | Genetics. Microbiology. Evolution & development. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
