| LDR | | 02499nam u200457 4500 |
| 001 | | 000000417943 |
| 005 | | 20190215162429 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780355968804 |
| 035 | |
▼a (MiAaPQ)AAI10822515 |
| 035 | |
▼a (MiAaPQ)grad.msu:16107 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 612 |
| 100 | 1 |
▼a Pohl, Calvin Seneca. |
| 245 | 10 |
▼a Homeostatic Responses of the Enteric Cholinergic System in Stress and Enteritis. |
| 260 | |
▼a [S.l.]:
▼b Michigan State University.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 239 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Adam J. Moeser. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Michigan State University, 2018. |
| 520 | |
▼a Stressful, traumatic events are a well-recognized trigger leading to acute and chronic gastrointestinal (GI) disease like Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD). Two major types of stress which are pervasive within th |
| 520 | |
▼a The enteric cholinergic nervous system is a major regulator of GI homeostasis with broad regulatory roles over epithelial barrier permeability, epithelial cell secretion, smooth muscle contraction and motility, and immune activation. Though a ro |
| 520 | |
▼a The objective of this dissertation was to determine if the enteric cholinergic nervous system contributed to GI disease under different types of environmental challenges including early life adversity, chronic stress and pathogen challenge. To a |
| 520 | |
▼a The results presented here demonstrate that different types of stressors differentially impact the enteric cholinergic system. Following early life adversity, we observed a persistent upregulation of the enteric cholinergic system, which predisp |
| 590 | |
▼a School code: 0128. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0719 |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a Michigan State University.
▼b Comparative Medicine and Integrative Biology - Doctor of Philosophy. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0128 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998481
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |