LDR | | 02086nam u200397 4500 |
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008 | | 181129s2017 |||||||||||||||||c||eng d |
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▼a 9780438170384 |
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▼a (MiAaPQ)AAI10680619 |
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▼a (MiAaPQ)umn:18758 |
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▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
082 | 0 |
▼a 574 |
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▼a Hauck, Amy Katherine. |
245 | 14 |
▼a The Role of Protein Carbonylation in the Adipocyte Nucleus. |
260 | |
▼a [S.l.]:
▼b University of Minnesota.,
▼c 2017. |
260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
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▼a 169 p. |
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▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
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▼a Adviser: David A. Bernlohr. |
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▼a Thesis (Ph.D.)--University of Minnesota, 2017. |
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▼a As the incidence of obesity rises globally, it has become increasingly imperative to identify the mechanisms that cause obesity-related metabolic disease. In particular, oxidative stress in the adipose tissue is known to cause metabolic dysfunct |
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▼a Protein carbonylation refers to the post-translational modification of lysine, cysteine, and histidine residues by diffusible electrophilic lipids. Specifically, 4- hydroxy-2-nonenal (4-HNE) and 4-hydroxy-2-hexenal (4-HHE) are produced at high l |
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▼a We found that protein carbonylation is elevated specifically in the nucleus of adipocytes as a consequence of obesity and of aging. Proteomic evaluation of these modifications revealed that the core histones and zinc finger proteins are major ta |
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▼a School code: 0130. |
650 | 4 |
▼a Biochemistry. |
690 | |
▼a 0487 |
710 | 20 |
▼a University of Minnesota.
▼b Biochemistry, Molecular Bio, and Biophysics. |
773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
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▼t Dissertation Abstract International |
790 | |
▼a 0130 |
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▼a Ph.D. |
792 | |
▼a 2017 |
793 | |
▼a English |
856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996716
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
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▼a 201812
▼f 2019 |
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▼a ***1012033 |