| LDR | | 02307nam u200409 4500 |
| 001 | | 000000418257 |
| 005 | | 20190215162720 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438078444 |
| 035 | |
▼a (MiAaPQ)AAI10684963 |
| 035 | |
▼a (MiAaPQ)berkeley:17493 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a De Leon, Justin A. |
| 245 | 10 |
▼a Mixed Signals: Regulation of Host Metabolism by an Intracellular Bacterial Pathogen. |
| 260 | |
▼a [S.l.]:
▼b University of California, Berkeley.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 59 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Russell E. Vance. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Berkeley, 2017. |
| 520 | |
▼a A hallmark of all pathogens is an ability to acquire nutrients from hosts. In order to do this, pathogens must overcome both the tight regulation of host nutrients and the host defense mechanisms deployed to protect these nutrients. |
| 520 | |
▼a In the introductory chapter of this dissertation, I begin with a discussion of innate immunity. I discuss the now appreciated view of the innate immune system as a sensor of patterns of pathogenesis. I then argue, based on our studies in Legione |
| 520 | |
▼a In chapter two, I provide experimental evidence that nutrient acquisition is a pattern of pathogenesis. I discuss my work describing how L. pneumophila alters a key metabolic signaling pathway, the mechanistic target of rapamycin complex 1 (mTOR |
| 520 | |
▼a I then close with a perspective chapter that describes the additional questions my work has given rise to and the state of the bacterial molecular pathogenicity field as a whole. |
| 590 | |
▼a School code: 0028. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a University of California, Berkeley.
▼b Molecular & Cell Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0028 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996742
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |