| LDR | | 02460nam u200433 4500 |
| 001 | | 000000418489 |
| 005 | | 20190215162914 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438349414 |
| 035 | |
▼a (MiAaPQ)AAI10842655 |
| 035 | |
▼a (MiAaPQ)unc:18061 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 576.6 |
| 100 | 1 |
▼a Gallichotte, Emily Newman. |
| 245 | 14 |
▼a The Human Antibody Response to DENV2 Infection and Vaccination. |
| 260 | |
▼a [S.l.]:
▼b The University of North Carolina at Chapel Hill.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 154 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Advisers: Aravinda de Silva |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a Dengue viruses (DENVs) are mosquito-borne flaviviruses that are estimated to infect 390 million people each year. Dengue is a major global public health concern because people infected with the virus can develop dengue fever or severe dengue hem |
| 520 | |
▼a There are four antigenically distinct DENV serotypes, named DENV1 through DENV4. For my studies, I focused on DENV2 as a model to understand human protective immunity following infection or vaccination. Following natural DENV2 infections, indivi |
| 520 | |
▼a I sought to determine if DENV vaccination is able to elicit the same types of DENV2 antibodies implicated in protective immunity following natural infections. I observed that two different live DENV vaccines were able to elicit antibodies target |
| 520 | |
▼a Investigators studying DENV pathogenesis and vaccines had previously focused on the functional properties (neutralization) of human antibodies, with little consideration of the actual epitopes and mechanisms of protective immunity. Recent result |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Virology. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0720 |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Microbiology and Immunology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999860
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |