| LDR | | 02225nam u200421 4500 |
| 001 | | 000000418510 |
| 005 | | 20190215162924 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438386150 |
| 035 | |
▼a (MiAaPQ)AAI10842948 |
| 035 | |
▼a (MiAaPQ)colorado:15617 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 612 |
| 100 | 1 |
▼a Newell-Stamper, Breanne L.
▼0 (orcid)0000-0002-5098-1965. |
| 245 | 10 |
▼a From Cells to Mice: Mutations Conferring Oxidative Stress-resistance on Longevity Phenotypes in the Mouse. |
| 260 | |
▼a [S.l.]:
▼b University of Colorado at Boulder.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 139 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B. |
| 500 | |
▼a Adviser: Thomas E. Johnson. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Colorado at Boulder, 2018. |
| 520 | |
▼a Oxidative stress is one of the drivers of the aging process and resistance to oxidative stress is a common characteristic of long-lived organisms. For these reasons, stress resistance has been recognized as a surrogate marker of longevity. Effor |
| 520 | |
▼a We assessed two metrics of healthspan, body weight (BW) and grip strength (GS), across the lifespan in both male and female mice. BW and GS are measures of general and neuromuscular health and are commonly assessed in mice and humans. We found t |
| 520 | |
▼a These studies are some of the few that longitudinally evaluate healthspan and lifespan in male and female mice of different genetic backgrounds. Collectively, our results show that genetic mutations conferring oxidative stress resistance slowed |
| 590 | |
▼a School code: 0051. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0719 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a University of Colorado at Boulder.
▼b Integrative Physiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-02B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0051 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999884
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |