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020 ▼a 9780438361713
035 ▼a (MiAaPQ)AAI10844118
035 ▼a (MiAaPQ)purdue:23160
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 247004
0820 ▼a 540
1001 ▼a Agrawal, Neha.
24510 ▼a Development of Trojan Horse Dimeric Inhibitors of P-Glycoprotein to Target HIV Reservoirs in the Brain.
260 ▼a [S.l.]: ▼b Purdue University., ▼c 2018.
260 1 ▼a Ann Arbor: ▼b ProQuest Dissertations & Theses, ▼c 2018.
300 ▼a 210 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
500 ▼a Adviser: Jean A. Chmielewski.
5021 ▼a Thesis (Ph.D.)--Purdue University, 2018.
520 ▼a HIV/AIDS has emerged as an incredibly serious infectious disease. The complete eradication of HIV is hindered by virus reservoir formation in the host. Some of the locations of these reservoirs include the central nervous system (CNS), resting m
520 ▼a All the TH heterodimeric were found to inhibit P-gp mediated efflux of fluorescent substrates in T-cells as well as model blood-brain barrier cell lines. Two TH heterodimeric were found to inhibit HIV-1 replication in 12D7 cells most effectively
590 ▼a School code: 0183.
650 4 ▼a Chemistry.
650 4 ▼a Organic chemistry.
650 4 ▼a Biochemistry.
690 ▼a 0485
690 ▼a 0490
690 ▼a 0487
71020 ▼a Purdue University. ▼b Chemistry.
7730 ▼t Dissertation Abstracts International ▼g 80-01B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0183
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999968 ▼n KERIS ▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다.
980 ▼a 201812 ▼f 2019
990 ▼a ***1012033