| LDR | | 02047nam u200397 4500 |
| 001 | | 000000418710 |
| 005 | | 20190215163103 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438354050 |
| 035 | |
▼a (MiAaPQ)AAI10845698 |
| 035 | |
▼a (MiAaPQ)umn:19529 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Green, Matthew V. |
| 245 | 10 |
▼a Neural Adaptations Following Exposure to HIV Proteins. |
| 260 | |
▼a [S.l.]:
▼b University of Minnesota.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 133 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Stanley A. Thayer. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a HIV associated neurocognitive disorders (HAND) affect nearly half of the population infected with HIV. Symptoms range from subclinical cognitive deficits to severe dementia which can affect daily living. The neurotoxicity produced is likely indi |
| 520 | |
▼a In this dissertation, I report viral proteins altering two types of receptors involved in regulating neuronal excitability and synaptic transmission, the excitatory NMDA receptor (NMDAR) and the inhibitory GABAAR. NMDARs initially become overact |
| 520 | |
▼a Second, I determined how the viral protein gp120 affects GABAergic inhibition. In hippocampal cultures, gp120 caused an increase in tonic GABAAR currents mediated by extrasynaptic GABAARs and an increase in the number of inhibitory synapses. Bot |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a University of Minnesota.
▼b Neuroscience. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000080
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |