| LDR | | 02590nam u200469 4500 |
| 001 | | 000000418792 |
| 005 | | 20190215163144 |
| 008 | | 181129s2015 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438051409 |
| 035 | |
▼a (MiAaPQ)AAI10867755 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1449218489 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Hussein, Hayam. |
| 245 | 10 |
▼a Cathepsin K Inhibition In Bone And Bone Marrow In Horses. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2015. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2015. |
| 300 | |
▼a 181 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Alicia Bertone. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2015. |
| 520 | |
▼a Cathepsin K (CatK), a cysteine protease, has been implicated in the process of bone resorption and inflammation. Selective inhibitors of CatK are promising therapeutic agents for the treatment of diseases associated with excessive bone loss and |
| 520 | |
▼a In the first phase of this work, we determined an optimal dose and dose interval for a CatK inhibitor (CatKI), VEL-0230, in healthy adult horses. Plasma pharmacokinetic (PK) and bone resorption biomarker [carboxy-terminal cross-linking telopepti |
| 520 | |
▼a In the second phase of this work, we evaluated bone structure and turnover in healthy young exercising horses receiving repeated oral dosing of a CatKI in a randomized, controlled, double-blinded, prospective, sufficiently powered clinical trial |
| 520 | |
▼a In the third phase of this work, we compared the effects of in vivo CatKI administration for 4 weeks to control vehicle administration for 4 weeks on equine bone marrow-derived stem and progenitor cells. Bone marrow was harvested from the stern |
| 520 | |
▼a In the fourth phase of work, we have studied two inflammatory models in equine bone marrow nucleated cells (BMNCs) |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biomedical engineering. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0541 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a The Ohio State University.
▼b Comparative and Veterinary Medicine. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2015 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000174
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |