| LDR | | 02456nam u200433 4500 |
| 001 | | 000000418799 |
| 005 | | 20190215163148 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438071476 |
| 035 | |
▼a (MiAaPQ)AAI10868347 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1509529255511222 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Komar, Hannah M. |
| 245 | 10 |
▼a Identifying Pathogenic Stromal and Acinar Signaling for Improved Diagnosis and Treatment of Chronic Pancreatitis. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 174 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Advisers: Gregory Lesinski |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Chronic pancreatitis (CP) is a devastating disease characterized by persistent inflammation and fibrosis of the pancreas leading to exocrine and endocrine insufficiency and increased risk of malignancy. Unfortunately, diagnosis of CP remains dif |
| 520 | |
▼a We hypothesized that the pro-survival Jak2/STAT3 and MAPK pathways play a role in PSC activation and proliferation and that these pathways would serve as therapeutic targets to reduce the pathogenic activity of these cells during disease. In vit |
| 520 | |
▼a To examine this hypothesis in vivo, we utilized the caerulein-induced murine model of chronic pancreatitis. Ruxolitinib was administered at 90mg/kg twice daily by oral gavage during the final week of caerulein treatment. Results show a trend tow |
| 520 | |
▼a To develop an experimental method to identify novel therapeutic and diagnostic biomarkers for CP, we hypothesized that proteomic analysis of pancreatic tissue from the caerulein-induced murine model of CP would elucidate candidate biomarkers of |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Biomedical engineering. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0541 |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a The Ohio State University.
▼b Biomedical Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000180
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |