LDR | | 02402nam u200409 4500 |
001 | | 000000418837 |
005 | | 20190215163206 |
008 | | 181129s2017 |||||||||||||||||c||eng d |
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▼a 9780438091528 |
035 | |
▼a (MiAaPQ)AAI10871374 |
035 | |
▼a (MiAaPQ)OhioLINK:osu1492739871307445 |
040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
082 | 0 |
▼a 610 |
100 | 1 |
▼a Volakis, Leonithas Ioannis. |
245 | 10 |
▼a Evaluating Dynamic Changes in Cancer Cell Mechanics during Epithelial to Mesenchymal Transition. |
260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2017. |
260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
300 | |
▼a 191 p. |
500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
500 | |
▼a Adviser: Samir Ghadiali. |
502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
520 | |
▼a Cancer metastasis is a major cause of mortality, with Epithelial-to-Mesenchymal Transition (EMT) playing a role in facilitating increased invasion and motility. During metastasis, epithelial cells detach from the primary tumor and may acquire a |
520 | |
▼a Currently, there is limited information about how the tumor's mechanical and biophysical properties influence EMT and metastasis. In Chapter 2, we address these knowledge gaps. Major findings for Chapter 2 include: (1) EMT progression using TGF- |
520 | |
▼a Following the canonical model, TGF-beta induced EMT in pancreatic cancer cells (Panc1) and non-cancer keratinocytes (HACAT) was evaluated. Major findings for Chapter 3 include: (1) In both models biomechanical features can assess EMT progression |
520 | |
▼a Results from Chapters 2 and 3 suggest that altering tumor mechanics is a viable way to mitigate the initial stages of metastasis, and cell adhesion and stiffness represent the robust biomechanical features during EMT progression. Chapter 4 build |
590 | |
▼a School code: 0168. |
650 | 4 |
▼a Biomedical engineering. |
690 | |
▼a 0541 |
710 | 20 |
▼a The Ohio State University.
▼b Biomedical Engineering. |
773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
773 | |
▼t Dissertation Abstract International |
790 | |
▼a 0168 |
791 | |
▼a Ph.D. |
792 | |
▼a 2017 |
793 | |
▼a English |
856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000220
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
980 | |
▼a 201812
▼f 2019 |
990 | |
▼a ***1012033 |