| LDR | | 02402nam u200409 4500 |
| 001 | | 000000418837 |
| 005 | | 20190215163206 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438091528 |
| 035 | |
▼a (MiAaPQ)AAI10871374 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1492739871307445 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Volakis, Leonithas Ioannis. |
| 245 | 10 |
▼a Evaluating Dynamic Changes in Cancer Cell Mechanics during Epithelial to Mesenchymal Transition. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 191 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Samir Ghadiali. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Cancer metastasis is a major cause of mortality, with Epithelial-to-Mesenchymal Transition (EMT) playing a role in facilitating increased invasion and motility. During metastasis, epithelial cells detach from the primary tumor and may acquire a |
| 520 | |
▼a Currently, there is limited information about how the tumor's mechanical and biophysical properties influence EMT and metastasis. In Chapter 2, we address these knowledge gaps. Major findings for Chapter 2 include: (1) EMT progression using TGF- |
| 520 | |
▼a Following the canonical model, TGF-beta induced EMT in pancreatic cancer cells (Panc1) and non-cancer keratinocytes (HACAT) was evaluated. Major findings for Chapter 3 include: (1) In both models biomechanical features can assess EMT progression |
| 520 | |
▼a Results from Chapters 2 and 3 suggest that altering tumor mechanics is a viable way to mitigate the initial stages of metastasis, and cell adhesion and stiffness represent the robust biomechanical features during EMT progression. Chapter 4 build |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Biomedical engineering. |
| 690 | |
▼a 0541 |
| 710 | 20 |
▼a The Ohio State University.
▼b Biomedical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000220
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |