| LDR | | 02178nam u200421 4500 |
| 001 | | 000000418850 |
| 005 | | 20190215163213 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438092679 |
| 035 | |
▼a (MiAaPQ)AAI10871471 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1461200133 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a Natarajan, Gayathri. |
| 245 | 14 |
▼a The Use of a TEC Kinase Inhibitor, Ibrutinib, for the Development of Immunotherapies Against Cancer and Leishmaniasis. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2016. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2016. |
| 300 | |
▼a 134 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Abhay Satoskar. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2016. |
| 520 | |
▼a Proteins belonging to the TEC family of kinases are critical for the function of immune cells. One of the kinases in this family, BTK (Bruton's tyrosine kinase), is required for the function of B cells. BTK also plays key roles during the pathog |
| 520 | |
▼a In addition to treating B cell malignancies, ibrutinib can potentially target other immune cells expressing BTK, such as dendritic cell (DCs). DCs, known as 'sentinels of the immune system', survey the body for the presence of 'danger signals' f |
| 520 | |
▼a Since ibrutinib effectively inhibits the function of B cells, it could also be expanded for the treatment of infectious diseases involving B cells. B cells contribute to susceptibility to the parasitic, vector-borne disease cutaneous leishmanias |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Microbiology. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0410 |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a The Ohio State University.
▼b Microbiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000232
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |