| LDR | | 02471nam u200421 4500 |
| 001 | | 000000418905 |
| 005 | | 20190215163240 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438098480 |
| 035 | |
▼a (MiAaPQ)AAI10901909 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1503248777003095 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616.01 |
| 100 | 1 |
▼a Kohart, Nicole Ann. |
| 245 | 10 |
▼a Models, Mechanisms, and Treatment of Adult T-cell Leukemia/Lymphoma Bone Metastasis. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 221 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Thomas Rosol. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Adult T-cell Leukemia/Lymphoma (ATL) is a rapidly fatal hematological malignancy that develops in a subset of Human T-cell Leukemia Virus Type 1 (HTLV-1) carriers after a 20-40 year latency. ATL has a unique relationship to bone characterized by |
| 520 | |
▼a Several animal models exist to study the pathogenesis of HTLV-1 and ATL |
| 520 | |
▼a Elevated levels of bone acting factors PTHrP, interleukin-6 (IL-6), and macrophage inflammatory protein-1alpha (MIP-1alpha) are found in serum of patients with ATL. Studies have defined an endocrine role for these factors to act on osteoclasts a |
| 520 | |
▼a To investigate new treatments for ATL bone metastases, we selected two agents that have demonstrated success in other bone-tropic neoplasms but have not been evaluated in ATL. Histone deacetylase inhibitors (HDACi) are a class of anti-cancer age |
| 520 | |
▼a In this dissertation research, we established and characterized novel mouse models of ATL bone metastasis for preclinical and pathogenesis studies of ATL. We found several bone-acting factors expressed in ATL bone tumors, notably high PTHrP expr |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Pathology. |
| 690 | |
▼a 0571 |
| 710 | 20 |
▼a The Ohio State University.
▼b Comparative and Veterinary Medicine. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000319
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |