| LDR | | 02153nam u200385 4500 |
| 001 | | 000000418946 |
| 005 | | 20190215163259 |
| 008 | | 181129s2015 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438110496 |
| 035 | |
▼a (MiAaPQ)AAI10902388 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Griggs, Ryan B. |
| 245 | 10 |
▼a Targeting Methylglyoxal and PPAR Gamma to Alleviate Neuropathic Pain Associated with Type 2 Diabetes. |
| 260 | |
▼a [S.l.]:
▼b University of Kentucky.,
▼c 2015. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2015. |
| 300 | |
▼a 269 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Kentucky, 2015. |
| 520 | |
▼a Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States. Neuropathic pain in diabetes manifests as a disease of the peripheral and central nervous systems. The prevalence of type 2 diabetes is far greater than |
| 520 | |
▼a I used methodological approaches including: (1) immunohistochemical and calcium imaging to assess stimulus-evoked sensitization |
| 520 | |
▼a I hypothesized that the thiazolidinedione class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists would reduce neuropathic pain-like behavior and spinal neuron sensitization in traumatic nerve injury and type 2 diabetes. A |
| 520 | |
▼a I aimed to investigate the contribution of the glucose metabolite methylglyoxal to painful type 2 diabetes. I tested the hypothesis that methylglyoxal produces nociceptive, evoked, and affective pain that is dependent on activation of the sensor |
| 590 | |
▼a School code: 0102. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a University of Kentucky.
▼b Physiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0102 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2015 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000365
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |