| LDR | | 02072nam u200421 4500 |
| 001 | | 000000418947 |
| 005 | | 20190215163300 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438110649 |
| 035 | |
▼a (MiAaPQ)AAI10902403 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Maimaiti, Shaniya. |
| 245 | 10 |
▼a Insulin Actions on Hippocampal Neurons. |
| 260 | |
▼a [S.l.]:
▼b University of Kentucky.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 164 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Kentucky, 2017. |
| 520 | |
▼a Aging is the main risk factor for cognitive decline. The hippocampus, a brain region critical for learning and memory formation, is especially vulnerable to normal and pathological age-related cognitive decline. Dysregulation of both insulin and |
| 520 | |
▼a We found that intranasal insulin improved memory in aged F344 rats. Young and aged F344 rats were treated with HumalogRTM, a short-acting insulin analog, or LevemirRTM, a long-acting insulin analog. The aged rats performed similar to young rats |
| 520 | |
▼a These results suggest that increasing brain insulin levels in aged rats may have improved memory by reducing the AHP and intracellular Ca2+concentrations. This study indicates a possible mechanism responsible for the beneficial effects of intran |
| 590 | |
▼a School code: 0102. |
| 650 | 4 |
▼a Pharmacology. |
| 650 | 4 |
▼a Neurosciences. |
| 650 | 4 |
▼a Aging. |
| 690 | |
▼a 0419 |
| 690 | |
▼a 0317 |
| 690 | |
▼a 0493 |
| 710 | 20 |
▼a University of Kentucky.
▼b Pharmacology and Nutritional Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0102 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000367
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |