| LDR | | 02319nam u200409 4500 |
| 001 | | 000000419025 |
| 005 | | 20190215163337 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438125872 |
| 035 | |
▼a (MiAaPQ)AAI10902981 |
| 035 | |
▼a (MiAaPQ)umichrackham:001266 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Taitano, Sophina Horne. |
| 245 | 10 |
▼a Role of TH2 Cytokines in Regulatory B Cell Biology. |
| 260 | |
▼a [S.l.]:
▼b University of Michigan.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 129 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Advisers: Nicholas W. Lukacs |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a B cells are now appreciated to be far more than antibody secreting cells. Throughout the last two decades B cells have been described to utilize a vast array of mechanisms to influence immune responses. Immune tolerance is achieved by a network |
| 520 | |
▼a To understand how regulatory B cells are modulated during allergic responses, we investigated the effects of TH2 cytokines (IL-5 and IL-4) on their regulatory function and growth in vitro. Previously, the lab reported that culture with CD40 liga |
| 520 | |
▼a Similar in vitro cultures were performed with human B cells from the peripheral blood. Inhibitors were used to target signaling pathways downstream of CD40L and IL-5 stimulation to understand the necessary pathways for regulatory B cells growth |
| 520 | |
▼a Together this work provides insight into the modulation of regulatory B cells during allergic inflammation. We also identify possible targets to further investigate as therapeutics to enhance or inhibit regulatory B cell activity. Many protectiv |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a University of Michigan.
▼b Immunology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000489
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |