| LDR | | 02404nam u200409 4500 |
| 001 | | 000000419028 |
| 005 | | 20190215163339 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438125902 |
| 035 | |
▼a (MiAaPQ)AAI10902984 |
| 035 | |
▼a (MiAaPQ)umichrackham:001101 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616.01 |
| 100 | 1 |
▼a Ting, Hung-An. |
| 245 | 10 |
▼a Notch Ligand Delta-like 4 (Dll4) Induces Epigenetic Mechanism in Regulatory T Cell Function During Pulmonary Viral Infection. |
| 260 | |
▼a [S.l.]:
▼b University of Michigan.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 152 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Nicholas W. Lukacs. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Respiratory Syncytial Virus (RSV) infects more than 90% of children under two years of age. It is the number one leading cause of hospitalizations for infants and young children. Inpatients suffer from RSV-induced moderate to severe bronchioliti |
| 520 | |
▼a The current dissertation demonstrates that Dll4 was up-regulated by RSV infection especially on CD11b+ pulmonary dendritic cells (DC). Using systemic Dll4 neutralization and a Dll4 knockdown DC transfer model, we found that Dll4 enhanced Foxp3 e |
| 520 | |
▼a Using an epigenetic enzyme PCR array, we found that Dll4 and Notch signaling enhanced the expression of a novel histone methyltransferase-SET and MYND domain containing protein 3 (SMYD3) in vitro and in vivo during RSV infection. SMYD3 catalyze |
| 520 | |
▼a Collectively, the studies in this dissertation suggest that Notch and its ligand Dll4 augment immunomodulatory Treg cell programs to ameliorate RSV immunopathology in part through an epigenetic mechanism-SMYD3. The results presented herein lay t |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Pathology. |
| 690 | |
▼a 0571 |
| 710 | 20 |
▼a University of Michigan.
▼b Molecular and Cellular Pathology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000492
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |