| LDR | | 02176nam u200445 4500 |
| 001 | | 000000419235 |
| 005 | | 20190215163520 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438117693 |
| 035 | |
▼a (MiAaPQ)AAI10831060 |
| 035 | |
▼a (MiAaPQ)mayo:10504 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Chen, Xiaoyue. |
| 245 | 10 |
▼a Epigenetic Abnormalities in Brain Tumors. |
| 260 | |
▼a [S.l.]:
▼b College of Medicine - Mayo Clinic.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 125 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Advisers: Zhiguo Zhang |
| 502 | 1 |
▼a Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2018. |
| 520 | |
▼a Epigenetics is the study of heritable changes that alters gene expression without changing DNA sequence. Previous studies showed that epigenetic alterations were associated with tumor initiation, progression and the development of chemo-resistan |
| 520 | |
▼a MGMT promoter methylation is one of the most important glioblastoma biomarkers. Hypermethylation of this promoter is associated with a lower MGMT expression and a higher efficacy of TMZ therapy. However, MGMT promoter methylation state does not |
| 520 | |
▼a Besides the development of resistance, epigenetic alterations play an important role in the initiation of DIPG. However, whether epigenetic alterations can be targeted to treat DIPG is unknown. In Chapter III, I show that inhibiting histone deme |
| 590 | |
▼a School code: 1542. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a College of Medicine - Mayo Clinic.
▼b Biochemistry and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 1542 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999494
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |