| LDR | | 02982nam u200481 4500 |
| 001 | | 000000419402 |
| 005 | | 20190215163640 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438353442 |
| 035 | |
▼a (MiAaPQ)AAI10838981 |
| 035 | |
▼a (MiAaPQ)umn:19455 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616.99 |
| 100 | 1 |
▼a Elahi-Gedwillo, Kianna Y. |
| 245 | 10 |
▼a Stroma-Targeting Therapies and Local Intervention in Pancreatic Ductal Adenocarcinoma. |
| 260 | |
▼a [S.l.]:
▼b University of Minnesota.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 139 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Paolo P. Provenzano. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest forms of cancer, in part, because it is largely refractory to current therapies. The failure of most standard therapies, as well as promising immune therapies, may be largely as |
| 520 | |
▼a In Chapter 1, we lay the groundwork to understand the unique pathology of PDA and the relatively recent---and at times, controversial---history of STT. We review the antifibrotic agent, halofuginone (HF), which is utilized in the majority of the |
| 520 | |
▼a In Chapter 2, the experimental methods used to conduct these studies are described in detail, including the genetically-engineered KPC mouse model our lab employs and the associated intervention studies that these mice were enrolled in. |
| 520 | |
▼a In Chapter 3, we present the results of our effort to disrupt the severe biophysical barriers characteristic of PDA through stromal re-engineering. This was largely done using the potent antifibrotic agent, HF. In an autochthonous, genetically e |
| 520 | |
▼a In Chapter 4, we explored the therapeutic potential of local intervention in PDA through IRE. PDA is unable to be treated by a majority of focal therapies used in the clinic, such as heat-based radiofrequency, due to the sensitivity of the pancr |
| 520 | |
▼a In Chapter 5, we summarize our findings and conclusions, discussing the broader implications of these results. Finally, we outline the future directions that these studies ought to go in. The experiments outlined are expected to flesh out the me |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Therapy. |
| 650 | 4 |
▼a Biomedical engineering. |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0212 |
| 690 | |
▼a 0541 |
| 710 | 20 |
▼a University of Minnesota.
▼b Biomedical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999663
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |