| LDR | | 02609nam u200421 4500 |
| 001 | | 000000419958 |
| 005 | | 20190215164107 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438360600 |
| 035 | |
▼a (MiAaPQ)AAI10934077 |
| 035 | |
▼a (MiAaPQ)wisc:15763 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Lewis, Sarah A. |
| 245 | 14 |
▼a The Tmem135 Overexpression Mouse: A New Model of Cardiomyopathy. |
| 260 | |
▼a [S.l.]:
▼b The University of Wisconsin - Madison.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 114 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Akihiro Ikeda. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a The process of aging is the decline of an organism's lifespan and is defined by changes at distinct levels of organizational structures: molecular, cellular, tissue level, and systemic. Aging increases the susceptibility for disease states that |
| 520 | |
▼a The basis of my thesis is the study of transmembrane protein 135 ( Tmem135), whose anomalous expression leads to aging and age-related disease phenotypes. TMEM135 is a highly conserved protein that localizes to the outer membrane of mitochondria |
| 520 | |
▼a In Chapter 1, we examined the effect of Tmem135 overexpression in the adult mouse heart. The heart, like the retina, has high energy demands met largely by mitochondria. Perturbations in mitochondrial dynamics and functions have detrimental effe |
| 520 | |
▼a In Chapter 2, we sought to identify factors that interact with Tmem135 to help further elucidate TMEM135 functions in the heart. We found that overexpression of Tmem135 on the mixed genetic background (FVB and C57BL6/J) leads to sudden death in |
| 520 | |
▼a Our study indicates that mitochondrial dynamics are important for the maintenance of normal heart function and may have significant roles in the aging of the heart. We also identified molecular pathways that are affected by overexpression of Tme |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Genetics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001167
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |