| LDR | | 02708nam u200469 4500 |
| 001 | | 000000420216 |
| 005 | | 20190215164311 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438344129 |
| 035 | |
▼a (MiAaPQ)AAI10846622 |
| 035 | |
▼a (MiAaPQ)cornellgrad:11030 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 641 |
| 100 | 1 |
▼a Riddle, Emily Suzanne. |
| 245 | 10 |
▼a Characterizing Heterogeneity in the Regenerative Capacity of Human Muscle Progenitor Cells. |
| 260 | |
▼a [S.l.]:
▼b Cornell University.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 174 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Anna Thalacker-Mercer. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Cornell University, 2018. |
| 520 | |
▼a Skeletal muscle regeneration following muscle damage is imperative to maintain skeletal muscle structure and function throughout the lifespan. Regeneration requires a complex series of events including activation of skeletal muscle specific stem |
| 520 | |
▼a To evaluate the age- and sex-related differences in expansion capacity of primary hMPCs, we compared markers of expansion between young and old, male and female primary hMPC cultures. hMPCs from older males have reduced expansion capacity compa |
| 520 | |
▼a Using K-means cluster analysis and measurements of culture population doubling time and saturation density, we are the first to unbiasedly cluster cultures with similar growth parameters and to identify drivers of expansion capacity that weren't |
| 520 | |
▼a Acute inflammation following muscle injury is essential to activate satellite cells. However, chronic muscle inflammation likely contributes to impaired regenerative capacity in skeletal muscle. Previous research has identified muscle inflammato |
| 520 | |
▼a This dissertation highlights the heterogeneity that exists between humans throughout the muscle regenerative process. Uncovering the molecular underpinnings of this heterogeneity is essential as the field of medicine moves towards a personalized |
| 590 | |
▼a School code: 0058. |
| 650 | 4 |
▼a Nutrition. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0570 |
| 690 | |
▼a 0719 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a Cornell University.
▼b Nutrition. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0058 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000144
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |