| LDR | | 03942nam u200409 4500 |
| 001 | | 000000420289 |
| 005 | | 20190215164346 |
| 008 | | 190108s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438339910 |
| 035 | |
▼a (MiAaPQ)AAI10933270 |
| 035 | |
▼a (MiAaPQ)wisc:15698 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 612 |
| 100 | 1 |
▼a Haraldsdottir, Kristin. |
| 245 | 10 |
▼a Cardiovascular Structure and Function in Adolescents Born Preterm. |
| 260 | |
▼a [S.l.]:
▼b The University of Wisconsin - Madison.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 169 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Marlowe W. Eldridge. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a Introduction: Preterm birth disrupts the development of vital organ systems. Recent evidence demonstrates that young adults born preterm have higher incidence of hypertension, cardiac dysfunction, autonomic dysfunction, and exercise intolerance. This dissertation sought to determine exercise capacity, autonomic function and cardiac structure and function in adolescents born preterm. This dissertation hypothesized that adolescents born prematurely would have lower exercise capacity, muscular strength and power compared with age-matched controls, exhibit altered autonomic function, and that adolescents born prematurely would exhibit a blunted SV response to exercise, impaired diastolic function at rest, cardiac hypertrophy and lower ejection fractions compared to term-born controls. |
| 520 | |
▼a Methods: 21 preterm-born and 20 term-born adolescents born in 2003 and 2004 completed the study. Participants underwent progressive maximal metabolic exercise testing. Resting heart rate variability and heart rate recovery following maximal exercise were determined to assess autonomic function. Resting and exercise cardiac structure and function measurements were acquired by cardiac MRI using a 3-T GE scanner. |
| 520 | |
▼a Results: Preterm-born adolescents had lower absolute maximal aerobic capacity than term-born adolescents and lower maximal power, despite similar physical activity scores. Muscular strength was similar between groups, and preterm adolescents had significantly lower cardiac output at 50, 75 and 100% of maximal exercise effort, driven by lower stroke volume. Preterm-born subjects had lower time-domain HRV. HRR after maximal exercise was slower in preterm-born subjects at one and two minutes. |
| 520 | |
▼a Conclusions: This dissertation is the most comprehensive analysis of factors that impact exercise capacity, and its findings suggest two potential mechanisms driving impaired exercise capacity in preterm born individuals. First, the finding of lower HRV and HRR suggest impaired autonomic function, which could lead to diminished contractility of the heart in response to increasing demand. Second, our finding of a lower end diastolic volume with a lower diastolic circumferential strain velocity suggests a potential diastolic dysfunction, which would limit the ability of the ventricles to increase EDV as HR increases in response to exercise, thus resulting in lower SV reserve. These data will significantly contribute to our understanding of the development of the preterm cardiovascular system, autonomic nervous system, and heart into adolescence. |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Physiology. |
| 690 | |
▼a 0719 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Kinesiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15013690
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |