| LDR | | 02698nam u200445 4500 |
| 001 | | 000000420678 |
| 005 | | 20190215164652 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438173521 |
| 035 | |
▼a (MiAaPQ)AAI10786768 |
| 035 | |
▼a (MiAaPQ)washington:18410 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Nguyen, Huong Thi Huynh. |
| 245 | 10 |
▼a Structural Elucidation of Gas-Phase Peptide Ions by Tandem Mass Spectrometry and Molecular Dynamics Simulations. |
| 260 | |
▼a [S.l.]:
▼b University of Washington.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 247 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Frantisek Turecek. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2018. |
| 520 | |
▼a The invention of the mass spectrometer has enabled scientists to discover numerous fascinating reactive gas-phase chemical species such as peptide cation radicals. The generation of these radicals can be accomplished via several methods includin |
| 520 | |
▼a There are several methods available for probing the conformational structures of gas-phase ions such as collision-induced dissociation (CID), ion mobility (IM), infrared multiphoton dissociation (IRMPD), and UV-Vis photodissociation (UVPD). CID |
| 520 | |
▼a In the first part of this work, which includes Chapters 2--5, the electronic structures of ETD-formed z-fragment ions were studied in detail using tandem mass spectrometry and molecular dynamics simulations. Chapter 2 investigates the photoreact |
| 520 | |
▼a In a further attempt to investigate the 3D structures of peptide ions in the gas phase, we also explored the chemistry of diazirine as a way to freeze the conformations of the ion before subjecting it to structural analysis. Diazirine has been u |
| 520 | |
▼a In part II of this work, which includes Chapter 6, the chemistry of diazirines was implemented to study non-covalent interactions of peptide complexes generated in the gas phase. Specifically, we incorporated diazirine-tagged amino acids (photol |
| 590 | |
▼a School code: 0250. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Analytical chemistry. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0486 |
| 710 | 20 |
▼a University of Washington.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0250 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997365
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |