| LDR | | 03207nam u200493 4500 |
| 001 | | 000000421003 |
| 005 | | 20190215164949 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438031586 |
| 035 | |
▼a (MiAaPQ)AAI10810516 |
| 035 | |
▼a (MiAaPQ)umn:19117 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Dauer, Patricia. |
| 245 | 10 |
▼a Endoplasmic Reticulum Stress-Mediated Signaling in Pancreatic Cancer. |
| 260 | |
▼a [S.l.]:
▼b University of Minnesota.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 142 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Ashok K. Saluja. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a Pancreatic ductal adenocarcinoma (PDAC) ranks among the poorest prognoses for cancer patients, with an estimated 5-year survival of just 8%. The stagnant survival rates are a result of late detection, chemoresistance, and an aggressive tumor phe |
| 520 | |
▼a One promising pharmacological advancement is currently undergoing a Phase II clinical trial and has been studied by our laboratory. Triptolide is a Chinese herb, which has shown to be very effective in eliminating pancreatic cancer cells in vitr |
| 520 | |
▼a The initial study in this dissertation precipitated based on an earlier finding in the Saluja laboratory that triptolide not only downregulates heat shock protein 70 (HSP70) and specificity protein 1 (SP1), but also causes chronic endoplasmic re |
| 520 | |
▼a Even though ER stress can result in cell death, it is initially a homeostatic mechanism, which aims to protect cells. This led us to ask what role acute ER stress and UPR plays in pancreatic cancer. We show that modulating glucose regulatory pro |
| 520 | |
▼a Our investigation into acute ER stress led to further studies to characterize the UPR signaling in pancreatic cancer. We show that shGRP78 dysregulates multiple transcriptomic and proteomic pathways important in cancer (proliferation, survival, |
| 520 | |
▼a The last study in this dissertation focuses on the tumor microenvironment and SP1 oncogenic signaling. We evaluated the transcriptomic profiling conducted after treatment with triptolide revealed deregulation of the transforming growth factor be |
| 520 | |
▼a These studies underscore the importance of ER stress and understanding the complex balance of adaptation versus cell death in pancreatic cancer. We have identified SP1 and GRP78 as potential targets for future PDAC therapies. These findings have |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Pharmacology. |
| 650 | 4 |
▼a Cellular biology. |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0419 |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a University of Minnesota.
▼b Pharmacology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997945
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |