| LDR | | 02405nam u200457 4500 |
| 001 | | 000000421482 |
| 005 | | 20190215165342 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438047860 |
| 035 | |
▼a (MiAaPQ)AAI10815406 |
| 035 | |
▼a (MiAaPQ)princeton:12523 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 620.11 |
| 100 | 1 |
▼a Hu, Jingjie. |
| 245 | 10 |
▼a Breast Cancer Detection: From Tumor-specific Nanoparticles to Cell Mechanics. |
| 260 | |
▼a [S.l.]:
▼b Princeton University.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 171 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Winston O. Soboyejo. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Princeton University, 2018. |
| 520 | |
▼a This thesis presents combined experimental and theoretical studies of cancer cell mechanics and peptide-enhanced nanoparticle entry/adhesion to triple negative breast cancer (TNBC) cells. |
| 520 | |
▼a The adhesive interaction between functionalized nanoparticles and biological cells is critical for effective cancer targeting. A combination of atomic force microscopy (AFM) and simulation approaches are used to evaluate the adhesion and molecul |
| 520 | |
▼a To investigate Triptorelin-MNP cluster entry mechanism and cellular uptake efficacy, thermodynamics and kinetics modeling and optical/confocal fluorescence microscopy are used to show that Triptorelin ligands enhance the uptake of Triptorelin-MN |
| 520 | |
▼a Finally, a cell mechanics approach is explored for TNBC cell detection. This involves the use of a shear assay technique, in parallel with digital image correlation and a Maxwell model for the measurements of viscoelastic properties as effective |
| 590 | |
▼a School code: 0181. |
| 650 | 4 |
▼a Materials science. |
| 650 | 4 |
▼a Bioengineering. |
| 650 | 4 |
▼a Nanotechnology. |
| 690 | |
▼a 0794 |
| 690 | |
▼a 0202 |
| 690 | |
▼a 0652 |
| 710 | 20 |
▼a Princeton University.
▼b Mechanical and Aerospace Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0181 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998171
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |