| LDR | | 02052nam u200397 4500 |
| 001 | | 000000421608 |
| 005 | | 20190215165444 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438027121 |
| 035 | |
▼a (MiAaPQ)AAI10816840 |
| 035 | |
▼a (MiAaPQ)cornellgrad:10848 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Wang, Wenke. |
| 245 | 14 |
▼a The Roles of Set-9 and Set-26 in Longevity, Germline Function and RNAi Pathway. |
| 260 | |
▼a [S.l.]:
▼b Cornell University.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 208 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Siu S. Lee. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Cornell University, 2018. |
| 520 | |
▼a Aging, germline function and RNA interference are three distinct biological processes that associate with alterations in epigenetic state, including histone modifications. Our lab discovered two highly homologous SET domain containing genes, set |
| 520 | |
▼a My work found that SET-26 but not SET-9 plays an important role in lifespan regulation. Endogenous SET-26 is broadly expressed while SET-9 is only detectable in the germline. Specifically, somatically expressed SET-26 is implicated in lifespan d |
| 520 | |
▼a SET-9 and SET-26 are putative homologs of the human protein Mixed Lineage Leukemia 5 (hMLL5), which plays an important role in regulating hematopoietic homeostasis, cell cycle and survival. However, the molecular basis underlying hMLL5 activity |
| 590 | |
▼a School code: 0058. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a Cornell University.
▼b Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0058 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998294
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |