| LDR | | 02757nam u200469 4500 |
| 001 | | 000000421708 |
| 005 | | 20190215165534 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438325173 |
| 035 | |
▼a (MiAaPQ)AAI10821704 |
| 035 | |
▼a (MiAaPQ)berkeley:17944 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 576.6 |
| 100 | 1 |
▼a TerBush, Allison Alwan. |
| 245 | 10 |
▼a Characterization of Receptor Use and Entry Mechanisms in Two KSHV Infection Systems. |
| 260 | |
▼a [S.l.]:
▼b University of California, Berkeley.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 129 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Laurent Coscoy. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Berkeley, 2018. |
| 520 | |
▼a Viruses initiate infection at the cell surface, where they use viral proteins to contact and manipulate naturally occurring host receptors in the plasma membrane. Through this interaction, viruses negotiate internalization and begin their infect |
| 520 | |
▼a Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an important human pathogen. It is the causative agent of several cancers and inflammatory disease which together, in the context of the global HIV epidemic, are a major public health burden. KSH |
| 520 | |
▼a Here we investigated KSHV receptor usage in cell types that are relatively understudied in the field: epithelial cells and lymphocytes. We uncovered novel variability in receptor use across many susceptible cell lines, particularly that infectio |
| 520 | |
▼a Furthermore, we showed that coculture-mediated infection of BJAB cells required heparan sulfate and Eph receptor interactions, despite the fact that BJAB cells do not express heparan sulfate and manipulation of Eph receptor expression did not af |
| 520 | |
▼a Our work reveals another layer of complexity beyond receptor availability on cells. It is now clear that even when KSHV receptors are expressed by a cell, additional contextual factors determine whether they play a role during infection. Going f |
| 590 | |
▼a School code: 0028. |
| 650 | 4 |
▼a Virology. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0720 |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a University of California, Berkeley.
▼b Molecular & Cell Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0028 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998405
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |