| LDR | | 02847nam u200469 4500 |
| 001 | | 000000422329 |
| 005 | | 20190215170035 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438081123 |
| 035 | |
▼a (MiAaPQ)AAI10828177 |
| 035 | |
▼a (MiAaPQ)ucla:16943 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Awad, Agape Mamdouh. |
| 245 | 10 |
▼a Characterization of the CoQ-Synthome Proteins and Binding Partners, Their Phosphorylation Status, and Alternative Splicing and Regulation in Saccharomyces cerevisiae. |
| 260 | |
▼a [S.l.]:
▼b University of California, Los Angeles.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 134 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Catherine F. Clarke. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 520 | |
▼a Coenzyme Q (also termed ubiquinone or Q) is an electron carrier in the mitochondrial respiratory chain that functions as an essential component in energy metabolism processes. Q transfers electrons from NADH and succinate to cytochrome c, a heme |
| 520 | |
▼a Saccharomyces cerevisiae (baker's yeast) serves as an excellent model for studies on Q because of its powerful molecular genetics and its close homology to human Q biosynthesis and function. Q biosynthesis in S. cerevisiae (which makes Q6 with s |
| 520 | |
▼a Chapter 2 investigates potential additional protein partners of the CoQ-Synthome. Via tandem affinity purification and proteomic and mass spectrometry analysis---facilitated by dualtagged Coq polypeptides---YLR290C was identified as a CoQ-Syntho |
| 520 | |
▼a Given the findings contained in Chapter 2 related to the association of Coq6 with the putative kinase of the system, Coq8, the question now remains whether Coq6 is a phosphorylated Coq polypeptide, similar to Coq3, Coq5, and Coq7. Chapter 3 furt |
| 520 | |
▼a Chapter 4 details the extensive story of alternative splicing in yeast, and in particular, as it relates to the Coenzyme Q biosynthetic pathway. Previous findings from another collaborating laboratory showed that Coq7 contained several phosphory |
| 590 | |
▼a School code: 0031. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Aging. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0493 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a University of California, Los Angeles.
▼b Biochemistry & Molecular Biology 0114. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0031 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999127
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |