| LDR | | 02891nam u200433 4500 |
| 001 | | 000000422492 |
| 005 | | 20190215170154 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438135024 |
| 035 | |
▼a (MiAaPQ)AAI10903677 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Hull, Chelsea M. |
| 245 | 10 |
▼a Mechanistic Investigation of Activation of the Innate Immune Sensor PKR by Various Levels and Types of RNA Structure. |
| 260 | |
▼a [S.l.]:
▼b The Pennsylvania State University.,
▼c 2016. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2016. |
| 300 | |
▼a 229 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a The innate immune response is the first line of defense against invading pathogens, thus it is of very critical importance to human health and medicine. There are many dangerous pathogens and microorganisms that threaten the human cell at all ti |
| 520 | |
▼a The protein kinase PKR is an essential protein in the innate immune response that upon recognition of pathogenic patterns is activated and eventually leads to apoptosis of this infected cell. PKR recognizes molecular patterns through unique path |
| 520 | |
▼a RNA molecules can adopt an array of structures and perform many different functions in the cell. It is important to understand both sides of the interaction between PKR and RNA because they are both functional molecules. Some pathogens are not r |
| 520 | |
▼a Much is already known about how PKR recognizes pathogenic RNA from viruses, but recently PKR has been shown to be activated in cells infected with RNA from bacteria. There are many levels of RNA structure found in the bacterial transcriptome whe |
| 520 | |
▼a I also expanded this into a detailed mechanistic study that different types of functional bacterial RNAs with extensive tertiary structure activate PKR including a riboswitch, a riboswitch-ribozyme, and a ribozyme. I showed that these bacterial |
| 520 | |
▼a Taking a step back and investigating PKR's interaction with RNA at the primary and secondary levels of RNA structure led to some findings that helped us understand how PKR can detect a broad range of RNA structure. At the primary level, our lab |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000668
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |