| LDR | | 02702nam u200445 4500 |
| 001 | | 000000422514 |
| 005 | | 20190215170204 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438135352 |
| 035 | |
▼a (MiAaPQ)AAI10903710 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Maldonado, Rebecca Jean Ramses Kaddis. |
| 245 | 10 |
▼a Nuclear Interactions of the Rous sarcoma Virus Gag Polyprotein with the Unspliced Viral RNA. |
| 260 | |
▼a [S.l.]:
▼b The Pennsylvania State University.,
▼c 2016. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2016. |
| 300 | |
▼a 254 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a Retroviruses are single-stranded RNA viruses that encode viral enzymes for the reverse transcription of the RNA genome into a DNA provirus, which integrates into the host chromosome. The integrated proviral DNA is transcribed into viral RNA (vRN |
| 520 | |
▼a Gag is thought to select the unspliced gRNA for packaging. Although it was previously thought that Gag functioned solely in the cytoplasm, the Gag proteins of multiple retroviruses have recently been observed to traffic through the nucleus. Data |
| 520 | |
▼a Under steady-state conditions RSV Gag is primarily located in the cytoplasm and at the plasma membrane with a small portion of the Gag present in the nucleus. To visualize Gag: vRNA complexes in the nucleus, we created an infectious proviral con |
| 520 | |
▼a Gag.L291A preferentially co-localizes with the vRNA in the nucleus. However, a low but consistent level of co-localization exists with non-viral and nascent RNAs, suggesting a localization mechanism tied to transcription. Gag.L219A co-localizes |
| 520 | |
▼a To determine whether Gag: RNA nuclear interactions are conserved among retroviruses, we utilized a cell line that contains a stably integrated, doxycycline-inducible HIV-1 provirus that expresses HIV-1 Gag fused to GFP. The unspliced HIV-1 RNA w |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Virology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0720 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Cell and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000691
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |