| LDR | | 02460nam u200433 4500 |
| 001 | | 000000422735 |
| 005 | | 20190215170350 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438024090 |
| 035 | |
▼a (MiAaPQ)AAI10189946 |
| 035 | |
▼a (MiAaPQ)wisc:13623 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Winston-Mcpherson, Gabrielle Noel. |
| 245 | 10 |
▼a Chemical Synthesis and Biological Evaluation of Novel Indole-containing Heterocycles. |
| 260 | |
▼a [S.l.]:
▼b The University of Wisconsin - Madison.,
▼c 2016. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2016. |
| 300 | |
▼a 226 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Weiping Tang. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2016. |
| 520 | |
▼a The Tang lab has developed several methodologies to generate indole containing heterocycles. These reactions are known as indole annulations. Considering that indole is present in several bioactive small molecules, we have studied the activity o |
| 520 | |
▼a Cardiovascular diseases (CVD) are one of the leading causes of death in humans world wide. Strongly associated with CVD are high low-density lipoprotein cholesterol (LDL-C) levels. This condition is known as hypercholesterolemia. Proprotein conv |
| 520 | |
▼a In partnership with Eli Lilly's Open Innovation Drug Discovery (OIDD) program, we have identified novel indole-containing heterocycles that reduce PCSK9 levels at low micromolar concentrations. Notably, our reported platinum catalyzed indole ann |
| 520 | |
▼a The aryl hydrocarbon receptor (AhR) has emerged as a target with therapeutic potential. It has been postulated that AhR may be a target for the treatment of benign prostatic hyperplasia, undesired immune response during organ transplantation, in |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Pharmaceutical Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996509
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |