| LDR | | 02460nam u200457 4500 |
| 001 | | 000000422829 |
| 005 | | 20190215170437 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438170346 |
| 035 | |
▼a (MiAaPQ)AAI10287524 |
| 035 | |
▼a (MiAaPQ)umn:18231 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Eiden, Carter G. |
| 245 | 10 |
▼a Room Temperature Chemoselective Phosphine Oxide Reduction and Mechanism-Based Inhibitors of BioA. |
| 260 | |
▼a [S.l.]:
▼b University of Minnesota.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 344 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Courtney Aldrich. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2017. |
| 520 | |
▼a The reduction of phosphine oxides with silanes occurs with high specificity and fidelity and represents one of the most useful methods for synthesis of phosphines. The chemoselectivity of this process also allows for in situ recycling of phosph |
| 520 | |
▼a Abnormal patterns in the reduction rates of phosphetane oxides by phenylsilane were noted, causing initiation of a comprehensive investigation of silane-mediated phosphine oxide reduction which revealed widespread misunderstandings of the reduct |
| 520 | |
▼a Mechanism-based inhibitors (MBIs) are widely employed in chemistry, biology, and medicine due to their exquisite specificity and sustained duration of inhibition. The global kinetic parameters kinact and KI have been used to characterize MBIs, b |
| 520 | |
▼a 1 inactivates tubercular BioA through a four-step mechanism, and kinetic analysis revealed the rate-limiting step is the removal of the alpha-proton of 1. This knowledge was subsequently applied to rationally design dihydro-4-pyranone 42, dihydr |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Organic chemistry. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0490 |
| 710 | 20 |
▼a University of Minnesota.
▼b Medicinal Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996596
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |