| LDR | | 02746nam u200457 4500 |
| 001 | | 000000422870 |
| 005 | | 20190215170457 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780355829778 |
| 035 | |
▼a (MiAaPQ)AAI10622099 |
| 035 | |
▼a (MiAaPQ)umd:18477 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Ganapati, Shweta.
▼0 (orcid)0000-0003-1955-2772. |
| 245 | 10 |
▼a Functionalized Acyclic Cucurbit[N]URIL Molecular Containers as Reversal Agents for Drugs. |
| 260 | |
▼a [S.l.]:
▼b University of Maryland, College Park.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 350 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Lyle Isaacs. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Maryland, College Park, 2017. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a The study of molecular containers has a prominent place in the scientific literature with many applications, including drug reversal. The clinical use of the cyclodextrin based reversal agent Bridion(TM) has greatly improved the post-operative s |
| 520 | |
▼a Chapter 1 introduces molecular containers, CB[n], and reports the use of the acyclic CB[n] known as Calabadion 2 as a broad spectrum reversal agent for NMBAs in rats. It also proposes the potential use of molecular containers as reversal agents |
| 520 | |
▼a Chapter 2 establishes that Calabadion 2 displays good to high levels of selectivity toward the NMBAs rocuronium, vecuronium, and cisatracurium both in vitro and based on simulations designed to capture the essence of the biological system. The e |
| 520 | |
▼a Chapter 3 establishes that CB[n] based molecular containers - Calabadion 1, Calabadion 2, and CB[7] display higher affinities than p-sulfocalix[4]arene and HP-beta-cyclodextrin toward a panel of illicit drugs for which there are currently no USF |
| 520 | |
▼a Chapter 4 discusses the synthesis and molecular recognition properties of three new acyclic CB[n] hosts IV-2a -- IV-2c which incorporate alkyl linkers of varying lengths- ethyl, hexyl, and decyl |
| 590 | |
▼a School code: 0117. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Organic chemistry. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0490 |
| 710 | 20 |
▼a University of Maryland, College Park.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0117 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996643
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a ***1012033 |