| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000432158 |
| 005 | | 20200224114337 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781088319468 |
| 035 | |
▼a (MiAaPQ)AAI13903237 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Yang, Ran. |
| 245 | 10 |
▼a Development and Applications of a Computational Method for Analyzing Biological Tubes and Cells. |
| 260 | |
▼a [S.l.]:
▼b Northwestern University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 136 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-03, Section: B. |
| 500 | |
▼a Advisor: Carthew, Richard W. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Biological tubes are essential for animal survival, and their functions are highly dependent on tube shape. Analyzing the contributions of cell shape and organization to the morphogenesis of small tubes has been hampered by the limitations of existing programs in quantifying cell geometry on highly curved tubular surfaces and calculating tube-specific parameters. I developed a computational tool called QuBiT (Quantitative Tool for Biological Tubes) and used it to analyze morphogenesis during embryonic Drosophila trachea development. Analysis in wildtype tracheal dorsal trunks (DT) found previously unknown anterior-to-posterior gradients of cell orientation and aspect ratio as well as periodicity in the organization of cells in the main tube. Furthermore, computational modeling of tracheal expansion suggests that cell intercalation and/or rearrangement occurs but is not necessary to maintain the integrity of the DT. Analysis of tracheal mutants revealed unexpected findings, including interactions between Src42 and FoxO, Uif, and the Na+/K+ ATPase, suggesting that Src42 is a central regulator of tube size. These results demonstrate the importance of a computational tool for analyzing the morphogenesis of small diameter biological tubes and are a great asset to elucidating the biomolecular and biophysical mechanisms of tube size regulation. |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a Northwestern University.
▼b Interdepartmental Biological Sciences (IBiS) Graduate Program. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-03B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15492442
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |