| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000432409 |
| 005 | | 20200224125316 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781085753234 |
| 035 | |
▼a (MiAaPQ)AAI13902581 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Hartmann, Michaelyn Ann. |
| 245 | 10 |
▼a Meiotic Crossover Patterning in Drosophila melanogaster. |
| 260 | |
▼a [S.l.]:
▼b The University of North Carolina at Chapel Hill.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 142 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-03, Section: B. |
| 500 | |
▼a Advisor: Sekelsky, Jeff |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Meiosis is an essential process to halve an organism's genome in preparation for transmission to the next generation. Recombination between homologous chromosomes is necessary for the proper segregation of chromosomes, and allows the generation of genetic diversity. Mistakes in meiosis can lead to aneuploidy, therefore, to minimize mistakes, recombination is a highly regulated process. Crossovers are patterned along a chromosome, and this patterning is dictated by three phenomena known as interference, assurance, and the centromere effect. Interference assures that a crossover does not occur too close to another crossover, assurance maintains that each chromosome gets at least one crossover, and the centromere effect suppresses crossovers that occur too close to the centromere. The work detailed in this dissertation first focuses on the proteins involved in crossover formation and then investigates the regulation of the suppression of centromere-proximal crossovers. I have gained insight into a potential endonuclease, Ankle1, as well as further elucidated the role of the mei-MCM complex in creating meiotic crossovers. In addition, I discovered that centromere-proximal crossover suppression is regulated both by the highly-repetitive heterochromatin adjacent to the centromere, as well as the protein-mediated centromere effect, which extends into the euchromatin and dissipates with distance from the centromere. Overall these findings have provided insight into the mechanisms of crossover formation and patterning and provided the foundation for future studies of meiotic crossover control. |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Genetics. |
| 650 | 4 |
▼a Cellular biology. |
| 690 | |
▼a 0369 |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Genetics and Molecular Biology. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-03B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15492384
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |