LDR | | 00000nam u2200205 4500 |
001 | | 000000432496 |
005 | | 20200224131406 |
008 | | 200131s2019 ||||||||||||||||| ||eng d |
020 | |
▼a 9781085694544 |
035 | |
▼a (MiAaPQ)AAI13898410 |
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▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
082 | 0 |
▼a 616 |
100 | 1 |
▼a Wagner, Catriona A. |
245 | 10 |
▼a How Myelin-Specific CD8 T Cells Contribute to CNS Autoimmunity. |
260 | |
▼a [S.l.]:
▼b University of Washington.,
▼c 2019. |
260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
300 | |
▼a 114 p. |
500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-03, Section: B. |
500 | |
▼a Advisor: Goverman, Joan. |
502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2019. |
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▼a This item must not be sold to any third party vendors. |
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▼a This item must not be added to any third party search indexes. |
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▼a Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). CD4 T cells are implicated in MS pathogenesis and have been the main focus of MS research using the animal model experimental autoimmune encephalomyelitis (EAE). However, the extensive clinical and pathological heterogeneity seen in MS suggests that multiple pathways may be involved. Substantial evidence from patients with MS point to a role for CD8 T cells in disease pathogenesis. The ability of myelin-specific CD8 T cells to induce CNS autoimmunity and to exacerbate EAE initiated by CD4 T cells demonstrates a pathogenic role |
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▼a School code: 0250. |
650 | 4 |
▼a Immunology. |
690 | |
▼a 0982 |
710 | 20 |
▼a University of Washington.
▼b Immunology. |
773 | 0 |
▼t Dissertations Abstracts International
▼g 81-03B. |
773 | |
▼t Dissertation Abstract International |
790 | |
▼a 0250 |
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▼a Ph.D. |
792 | |
▼a 2019 |
793 | |
▼a English |
856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15491939
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
980 | |
▼a 202002
▼f 2020 |
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▼a ***1008102 |
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▼a E-BOOK |