| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000433279 |
| 005 | | 20200225133157 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781085635882 |
| 035 | |
▼a (MiAaPQ)AAI13881638 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Lin, Ke-Chih. |
| 245 | 10 |
▼a Cancer Dynamics under a Chemotherapeutic Stress Gradient Using a Microfluidic in vitro Tumor Environment. |
| 260 | |
▼a [S.l.]:
▼b Princeton University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 132 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-03, Section: B. |
| 500 | |
▼a Advisor: Sturm, James C. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Princeton University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a In this dissertation, we use the microfluidic cancer-on-chip system we have developed to explore cancer population dynamics and how cancer acquires drug resistance. The microfluidic cell culture device, the "evolution accelerator" (EA), generates an in vitro landscape of stress heterogeneity across a tumor population. The system allows for high-magnification real-time observations of different cancer cell lines and downstream analysis of cell phenotype as a function of position on the stress landscape. With the EA technology, we investigate the adaptation and evolution dynamics in prostate cancer cell metapopulations under a stress landscape of a chemotherapeutic drug (docetaxel). High-resolution time-lapse scanning provides abundant information about the change in cell morphology, population dynamics, cell motility and cell migration over time on a cellular level.We further implement this technology to study quantitatively the emergence of polyploid, mesenchymal and stem-like cancer cells in the context of complex heterogeneous yet controllable in vitro environments with a spatially-varying drug concentration. Within our microfluidic stress landscape, we observe: (1) a previously-unobserved surprisingly large number of polyploid giant cancer cells (PGCCs) which emerged in a highly stressful region in response to chemotherapy |
| 590 | |
▼a School code: 0181. |
| 650 | 4 |
▼a Biomedical engineering. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Medicine. |
| 650 | 4 |
▼a Epidemiology. |
| 650 | 4 |
▼a Public health. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Health sciences. |
| 650 | 4 |
▼a Pathology. |
| 690 | |
▼a 0541 |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0573 |
| 690 | |
▼a 0571 |
| 690 | |
▼a 0566 |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0564 |
| 690 | |
▼a 0766 |
| 690 | |
▼a 0719 |
| 710 | 20 |
▼a Princeton University.
▼b Electrical Engineering. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-03B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0181 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15491196
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1816162 |
| 991 | |
▼a E-BOOK |