| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000433939 |
| 005 | | 20200226134327 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781088371787 |
| 035 | |
▼a (MiAaPQ)AAI22588853 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a Machas, Michael. |
| 245 | 10 |
▼a Investigating Strategies to Enhance Microbial Production of and Tolerance Towards Aromatic Biochemicals. |
| 260 | |
▼a [S.l.]:
▼b Arizona State University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 153 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B. |
| 500 | |
▼a Advisor: Nielsen, David R. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Arizona State University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 506 | |
▼a This item must not be added to any third party search indexes. |
| 520 | |
▼a Aromatic compounds have traditionally been generated via petroleum feedstocks and have wide ranging applications in a variety of fields such as cosmetics, food, plastics, and pharmaceuticals. Substantial improvements have been made to sustainably produce many aromatic chemicals from renewable sources utilizing microbes as bio-factories. By assembling and optimizing native and non-native pathways to produce natural and non-natural bioproducts, the diversity of biochemical aromatics which can be produced is constantly being improved upon. One such compound, 2-Phenylethanol (2PE), is a key molecule used in the fragrance and food industries, as well as a potential biofuel. Here, a novel, non-natural pathway was engineered in Escherichia coli and subsequently evaluated. Following strain and bioprocess optimization, accumulation of inhibitory acetate byproduct was reduced and 2PE titers approached 2 g/L - a ~2-fold increase over previously implemented pathways in E. coli. Furthermore, a recently developed mechanism toallow E. coli to consume xylose and glucose, two ubiquitous and industrially relevant microbial feedstocks, simultaneously was implemented and systematically evaluated for its effects on L-phenylalanine (Phe |
| 590 | |
▼a School code: 0010. |
| 650 | 4 |
▼a Chemical engineering. |
| 650 | 4 |
▼a Bioengineering. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0542 |
| 690 | |
▼a 0202 |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a Arizona State University.
▼b Chemical Engineering. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-04B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0010 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15493129
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |