| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000433966 |
| 005 | | 20200226134658 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781687908131 |
| 035 | |
▼a (MiAaPQ)AAI22619080 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Rosas Vargas, Daisy. |
| 245 | 10 |
▼a Effort Towards an Intermolecular Reductive-Heck Reaction with Homogeneous and Heterogeneous Palladium Catalysis. |
| 260 | |
▼a [S.l.]:
▼b Indiana University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 130 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-05, Section: B. |
| 500 | |
▼a Advisor: Cook, Silas. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Indiana University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Synthetic organic chemists have developed powerful methods to create carbon-carbon bonds, such as metal-catalyzed cross coupling reactions. Pd-catalyzed cross coupling reactions are essential in a synthetic chemist's toolbox to create Csp2 centers. However, Csp3 couplings remain limited due to undesired 棺-H elimination or sluggish transmetallation with organometallic reagents. This work utilizes a variant of the Heck reaction, the reductive-Heck reaction, to create the Csp3 centers. We investigated and gained insight into the important variables that affect relative rates of organometallic processes of the intermolecular reductive-Heck catalytic cycle using design of experiments and traditional once-variable-at-time optimization methods. After encountering chemoselective issues in organic solvents, we utilized water as a solvent to increase the effective concentration of the reaction and address the fast rate of early transmetallation. In the last portion of this work, a chemoselective reductive-Heck reaction catalyzed by Pd nanoparticles was discovered. This work highlights the underexplored intermolecular reductive-Heck reaction with homogeneous and heterogeneous Pd catalysis and challenges to outcompete 棺-H elimination to create new reaction pathways. |
| 590 | |
▼a School code: 0093. |
| 650 | 4 |
▼a Organic chemistry. |
| 650 | 4 |
▼a Nanotechnology. |
| 650 | 4 |
▼a Molecular chemistry. |
| 690 | |
▼a 0490 |
| 690 | |
▼a 0652 |
| 690 | |
▼a 0431 |
| 710 | 20 |
▼a Indiana University.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-05B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0093 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15493593
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |