| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000434031 |
| 005 | | 20200226135600 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781085742146 |
| 035 | |
▼a (MiAaPQ)AAI22584918 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Marcyk, Paul Tomas. |
| 245 | 10 |
▼a Iron-Catalyzed Functionalization of Alcohols and Alkenes: Forging Carbon-Heteroatom Bonds with Earth Abundant Metals. |
| 260 | |
▼a [S.l.]:
▼b Indiana University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 459 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-03, Section: B. |
| 500 | |
▼a Advisor: Cook, Silas . |
| 502 | 1 |
▼a Thesis (Ph.D.)--Indiana University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 506 | |
▼a This item must not be added to any third party search indexes. |
| 520 | |
▼a An efficient iron Lewis acid catalyst for the activation of alcohol and alkenes has been developed. Using abundant starting materials, unactivated alcohols are directly substituted with sulfonamide nucleophiles to form carbon-nitrogen bonds. By tethering the nucleophile to the electrophile in an intramolecular variant, a stereospecific mechanism is operative, transferring chiral information from secondary and even tertiary alcohols. In a related series of reactions, the same iron catalyst can be used to promote the hydrofunctionalization of unactivated alkenes. This system uses sulfonamides, primary and secondary alcohols, and select thiols to rapidly form carbon-nitrogen, carbon-oxygen, and carbon-sulfur bonds from simple alkene building blocks. Finally, these two paradigms are unified in an iron-catalyzed annulation reaction for the synthesis of tetrahydroisoquinolines. Starting from a benzylic alcohol and an unactivated alkene, the tandem iron-catalyzed alcohol substitution and hydroamination with a sulfonamide nucleophile, forms a biologically relevant six membered heterocyclic scaffold in a single synthetic step. |
| 590 | |
▼a School code: 0093. |
| 650 | 4 |
▼a Organic chemistry. |
| 650 | 4 |
▼a Chemistry. |
| 690 | |
▼a 0490 |
| 690 | |
▼a 0485 |
| 710 | 20 |
▼a Indiana University.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-03B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0093 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15492893
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |