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020 ▼a 9781392762523
035 ▼a (MiAaPQ)AAI22616978
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 247004
0820 ▼a 547
1001 ▼a Moore, Lucas Charles.
24510 ▼a Diastereoselective Additions of Anhydride Enolates and Nucleophilic Alkenes to Chiral Aldehyde-derived N-Tosyl Imines.
260 ▼a [S.l.]: ▼b University of California, Davis., ▼c 2019.
260 1 ▼a Ann Arbor: ▼b ProQuest Dissertations & Theses, ▼c 2019.
300 ▼a 236 p.
500 ▼a Source: Dissertations Abstracts International, Volume: 81-06, Section: B.
500 ▼a Advisor: Shaw, Jared T.
5021 ▼a Thesis (Ph.D.)--University of California, Davis, 2019.
506 ▼a This item must not be sold to any third party vendors.
520 ▼a Described herein are the detailed approaches towards several synthetic organic chemistry projects. Chapter one describes the development of a new formal [4 + 2] cycloaddition reaction involving enolizable anhydrides and N-sulfonyl imines. During the course of these studies, we observed unexpected diastereoselectivity when using chiral aldehyde-derived N- sulfonyl imines. Chapter two details an investigation into this unexpected diastereoselectivity and subsequent development of a Lewis acid-mediated diastereodivergent reaction. Chapter three describes the complex synthesis of the chiral N-sulfonyl imines used as substrates in chapters one and two. Chapter four details two partially successful total synthesis efforts towards structurally related marine natural products, chrysophaentin E and colpol. Finally, chapter five describes the synthesis of three DNA gyrase inhibitors, gyramides E-F, as well as the methods used to synthesize their precursors.
590 ▼a School code: 0029.
650 4 ▼a Organic chemistry.
690 ▼a 0490
71020 ▼a University of California, Davis. ▼b Chemistry.
7730 ▼t Dissertations Abstracts International ▼g 81-06B.
773 ▼t Dissertation Abstract International
790 ▼a 0029
791 ▼a Ph.D.
792 ▼a 2019
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15493434 ▼n KERIS ▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다.
980 ▼a 202002 ▼f 2020
990 ▼a ***1008102
991 ▼a E-BOOK