| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000434306 |
| 005 | | 20200226145332 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781392615171 |
| 035 | |
▼a (MiAaPQ)AAI27542769 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Sheth, Ravi U. |
| 245 | 10 |
▼a New Tools for Understanding and Engineering Complex Microbial Communities. |
| 260 | |
▼a [S.l.]:
▼b Columbia University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 356 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B. |
| 500 | |
▼a Advisor: Wang, Harris H. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Columbia University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Microbes exist in unfathomably diverse, dynamic and intricately structured ecosystems. However, we lack the tools to fully capture the complexity of these microbiomes, which in turn limits our ability to understand their ecology and function. Here, I address these shortcomings by developing new high-throughput measurement tools to characterize microbiomes across functionally distinct axes. First, from a synthetic biology perspective, I leverage the bacterial CRISPR-Cas immune system to enable a new class of population-wide passive recording devices in cells for capture temporally varying signals and horizontally transferred DNA sequences. Second, in the microbiome arena, I develop a new suite of tools (experimental and theoretical) to capture and analyze the spatiotemporal dynamics of microbiomes at macroscopic and microscopic length scales. Taken together, these measurements provide deep insights into the ecology of complex microbiomes, and constitute a suite of powerful new tools to study microbes in their native context. |
| 590 | |
▼a School code: 0054. |
| 650 | 4 |
▼a Bioengineering. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0202 |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a Columbia University.
▼b Cellular, Molecular and Biomedical Studies. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-04B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0054 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15494443
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |