LDR | | 00000nam u2200205 4500 |
001 | | 000000434574 |
005 | | 20200226155907 |
008 | | 200131s2019 ||||||||||||||||| ||eng d |
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▼a 9781687947451 |
035 | |
▼a (MiAaPQ)AAI22620583 |
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▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
082 | 0 |
▼a 616 |
100 | 1 |
▼a Arroyo, Enidza Nicole. |
245 | 10 |
▼a B Cells, Not Dendritic Cells, Prime the Dominant CD4+ Tfh Response to Plasmodium Infection. |
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▼a [S.l.]:
▼b University of Washington.,
▼c 2019. |
260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
300 | |
▼a 60 p. |
500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B. |
500 | |
▼a Advisor: Pepper, Marion. |
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▼a Thesis (Ph.D.)--University of Washington, 2019. |
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▼a This item must not be sold to any third party vendors. |
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▼a This item must not be added to any third party search indexes. |
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▼a CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood- stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression. We studied antigen-specific CD4+ Tfh cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response. We discovered that a dominant, phenotypically stable, CXCR5+ Tfh population emerges within the first four days of infection and results in a CXCR5+ CCR7+ Tfh/central memory T cell response that persists well after parasite clearance. We also found that CD4+ T cell priming by B cells was both necessary and sufficient to generate this Tfh-dominant response, whereas priming by conventional dendritic cells was dispensable. This study provides important insights into the development of CD4+ Tfh cells during Plasmodium infection and highlights the heterogeneity of antigen-presenting cells involved in CD4+ T cell priming. |
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▼a School code: 0250. |
650 | 4 |
▼a Immunology. |
690 | |
▼a 0982 |
710 | 20 |
▼a University of Washington.
▼b Immunology. |
773 | 0 |
▼t Dissertations Abstracts International
▼g 81-04B. |
773 | |
▼t Dissertation Abstract International |
790 | |
▼a 0250 |
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▼a Ph.D. |
792 | |
▼a 2019 |
793 | |
▼a English |
856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15493738
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
980 | |
▼a 202002
▼f 2020 |
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▼a ***1008102 |
991 | |
▼a E-BOOK |