| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000434931 |
| 005 | | 20200227111201 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781085671781 |
| 035 | |
▼a (MiAaPQ)AAI27536447 |
| 035 | |
▼a (MiAaPQ)umichrackham002157 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616.99 |
| 100 | 1 |
▼a Hawkins, Allegra G. |
| 245 | 10 |
▼a Wnt/Beta-Catenin Signaling and the Tumor Microenvironment in Ewing Sarcoma Progression. |
| 260 | |
▼a [S.l.]:
▼b University of Michigan.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 180 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-02, Section: B. |
| 500 | |
▼a Advisor: Lawlor, Elizabeth. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 506 | |
▼a This item must not be added to any third party search indexes. |
| 520 | |
▼a Metastasis remains the primary cause of death in cancer patients. The invasion-metastasis cascade is dependent on crosstalk between tumor cells and the tumor microenvironment, including stromal cells, extracellular matrix, and blood vessels, at both primary and distal sites. Ewing sarcoma is a bone and soft tissue tumor primarily affecting children and adolescents. Patients with only local disease have high survival rates of >70%. However, current treatment strategies for patients developing metastasis have dismal survival rates of < 20%, making it imperative to better understand the biological processes that drive Ewing sarcoma metastasis. Wnt/beta-catenin activation is correlated with worse overall survival in Ewing sarcoma patients and tumor cell autonomous changes in cytoskeletal organization |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Oncology. |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a University of Michigan.
▼b Cancer Biology. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-02B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15494273
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |