| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000435106 |
| 005 | | 20200227114851 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781392870372 |
| 035 | |
▼a (MiAaPQ)AAI27614467 |
| 035 | |
▼a (MiAaPQ)umichrackham002573 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Kennaley, Kelly. |
| 245 | 10 |
▼a Identification and Characterization of TPRKB Dependency in TP53 Deficient Cancers. |
| 260 | |
▼a [S.l.]:
▼b University of Michigan.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 171 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-06, Section: B. |
| 500 | |
▼a Advisor: Nikolovska-Coleska, Zaneta |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 506 | |
▼a This item must not be added to any third party search indexes. |
| 520 | |
▼a Tumor protein 53 (TP53) is a transcription factor involved in regulating various facets of cellular functionality from its canonical functions in DNA damage response, cell cycle arrest, and apoptosis, to newer roles in metabolism, protein translation, and more. TP53 is also the most frequently altered gene in human cancer, and identification of vulnerabilities imposed by TP53 alterations may enable development of effective therapeutic approaches. Through analyzing shRNA-screening data, we identified TP53RK binding protein (TPRKB) as the most significant vulnerability in TP53-mutated cancer cell lines. To date, TPRKB's only known role is as a poorly characterized member of the transfer RNA (tRNA)-modifying Endopeptidase-like and Kinase associated to transcribed Chromatin/Kinase, Endopeptidase and Other Proteins of small Size (EKC/KEOPS) complex, responsible for depositing the t6A37 modification on all ANN decoding tRNAs. In vitro and in vivo, across multiple benign-immortalized and cancer cell lines, we confirmed that TPRKB knockdown in TP53-null, TP53-mutated, and Mouse double minute 2 homolog (MDM2 |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a University of Michigan.
▼b Molecular & Cellular Pathology. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-06B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15494606
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |