| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000435126 |
| 005 | | 20200227115252 |
| 008 | | 200131s2017 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781687947734 |
| 035 | |
▼a (MiAaPQ)AAI27539188 |
| 035 | |
▼a (MiAaPQ)OhioLINKosu1495801301660324 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Henderson, Sally Erin. |
| 245 | 10 |
▼a Translating the Anti-Tumor/Anti-Cachectic Activity of AR-42, a Novel HDAC Inhibitor, into Pancreatic Cancer Therapy. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2017. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2017. |
| 300 | |
▼a 153 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-05, Section: B. |
| 500 | |
▼a Advisor: Chen, Ching-Shih. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Pancreatic cancer is the 3rd leading cause of cancer death in the United States and has a 5-year survival of less than 9% for all stages. Furthermore, cachexia, defined as severe weight loss due to depletion of muscle mass that is not reversible with conventional nutritional support, is seen in 85% of pancreatic cancer patients and contributes significantly to morbidity and mortality. Therefore, there is an urgent need to develop novel therapeutics that target tumor growth and muscle wasting in order to improve clinical outcomes. The first part of this study was aimed at evaluating the efficacy of AR-42, a novel histone deacetylase (HDAC) inhibitor developed in our laboratory, in suppressing tumor growth in mouse models of pancreatic cancer. The in vitro anti-proliferative activity of AR-42 was evaluated in six human pancreatic cancer cell lines. An AsPC-1 subcutaneous xenograft and transgenic KPfl/flC (LSL-KrasG12D |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Pharmacology. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0419 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a The Ohio State University.
▼b Comparative and Veterinary Medicine. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-05B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15494337
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |