| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000435246 |
| 005 | | 20200227165217 |
| 008 | | 200131s2014 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781687976970 |
| 035 | |
▼a (MiAaPQ)AAI27603088 |
| 035 | |
▼a (MiAaPQ)OhioLINKosu1397560686 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 614 |
| 100 | 1 |
▼a Hsu, En-Chi. |
| 245 | 10 |
▼a Targeting ILK to Eliminate IL-6 Induced Cancer Stem Cell Phenotype. |
| 260 | |
▼a [S.l.]:
▼b The Ohio State University.,
▼c 2014. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2014. |
| 300 | |
▼a 138 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-06, Section: B. |
| 500 | |
▼a Advisor: Chen, Ching-Shih. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2014. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Cancer stem cell (CSC) has been associated with the aggressive phenotype of cancer, including potent cancer initiation, drug resistance and metastasis. Triple negative breast cancer (TNBC), a breast cancer subtype with aggressive behavior and no effective targeting therapy, has been shown correlations with autocrine interleukin-6 (IL-6) dependent survival and increasing CSC population. The inflammatory cytokine IL-6 induces CSC by activating STAT3 and NF-觀B pathway. Integrin-linked kinase (ILK), which links cell-adhesion receptors, integrins and growth factors to the actin cytoskeleton and regulates multiple signaling pathways such as Akt, AP-1 and NF-觀B pathways, is highly expressed in various cancers. In breast cancer cell lines, we showed that ILK expression is tightly associated with IL-6 expression and Notch1 activation, which is important for maintaining the self-renewal capacity of CSC. The objective of this study is to characterize the regulatory interactions among IL-6, ILK, and Notch1 in breast CSC. Our work shows that IL-6 upregulated ILK expression via E2F1 which, in turn, amplified the IL-6-NF-觀B positive signaling loop and stimulated downstream Notch1 activation. We also identified a novel role for ILK in the maturation of gamma-secretase, which cleaves and activates Notch 1. Immunohistochemical staining of a human breast tumor tissue microarray revealed a positive correlation between ILK and IL-6 expression. Moreover, high ILK expression showed low relapse-free survival probability (P = 0.045) among subgroup of patients with high IL-6 expression. These data indicate an integral role of ILK in IL-6-mediated signaling and consequent induction in CSC |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Biomedical engineering. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Epidemiology. |
| 650 | 4 |
▼a Public health. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Health sciences. |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0572 |
| 690 | |
▼a 0541 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0573 |
| 690 | |
▼a 0566 |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0766 |
| 690 | |
▼a 0719 |
| 710 | 20 |
▼a The Ohio State University.
▼b Pharmacy. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-06B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2014 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15494585
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |