| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000435550 |
| 005 | | 20200228101209 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781392399156 |
| 035 | |
▼a (MiAaPQ)AAI27540961 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 615.9 |
| 100 | 1 |
▼a Falero Perez, Juliana M. |
| 245 | 10 |
▼a Cytochrome P450 1B1 and Astrocyte Function. |
| 260 | |
▼a [S.l.]:
▼b The University of Wisconsin - Madison.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 316 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B. |
| 500 | |
▼a Advisor: Sheibani, Nader. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a Cytochrome P450 1B1 (Cyp1b1) belongs to the Cytochrome P450 family of enzymes. It is expressed in extrahepatic epithelia, ocular tissues and exhibits a developmentally regulated pattern of expression. Recent studies show expression of Cyp1b1 in the neurovascular structures of the central nervous system including astrocytes (AC). Astrocytes have a prominent role in the integrity and function of the central nervous system including modulation of angiogenesis, neurogenesis and maintenance of neuroretinal function. We previously showed that Cyp1b1 expression plays a significant role in retinal vascular development and neovascularization during oxygen-induced ischemic retinopathy (OIR). We also showed that lack of Cyp1b1 expression in retinal endothelial cells and pericytes is associated with increased oxidative stress, sustained activation of NF-觀B, and up-regulation of thrombospondin-2 (TSP2 |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Ophthalmology. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Toxicology. |
| 690 | |
▼a 0381 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0383 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Molecular & Env Tox - PH. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-04B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15494413
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1816162 |
| 991 | |
▼a E-BOOK |